F9 - coagulation factor IX Gene

Also Known as FIX; P19; PTC; HEMB; THPH8; F9 p22

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2158

About F9

Cytogenetic location: Xq27.1 Genomic coordinates (GRCh38): X:139,530,739-139,563,459 (from NCBI)

This gene has 4 transcripts (splice variants), 216 orthologues, 16 paralogues and is associated with 7 phenotypes. Restricted expression toward liver (RPKM 181.1).

Summary

This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane Phospholipids, and Factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Sep 2015]

F9 Products (2)

mRNA	Protein	Name
NM_000133.4	NP_000124.1	coagulation factor IX isoform 1 preproprotein
NM_001313913.2	NP_001300842.1	coagulation factor IX isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	EXP EXP: Inferred from Experiment	14722079	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	9169594	GOA
enables endopeptidase activity	IDA IDA: Inferred from direct assay	2592373	GOA
enables metal ion binding	EXP EXP: Inferred from Experiment	14722079	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26157780	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in blood coagulation	IDA IDA: Inferred from direct assay	2472424	GOA
involved in blood coagulation	IMP IMP: Inferred from mutant phenotype	2592373	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	20121197	GOA
involved in zymogen activation	IDA IDA: Inferred from direct assay	2592373	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	2592373	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F9 Protein Structure

Gla

EGF

FXa_inhibition

Trypsin

0
100
200
300
400
461 a.a.

Protein Preferred Names	Protein Names
coagulation factor IX	Christmas factor

Recombinant F9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70231	Coagulation factor IX/F9 Protein, Human (HEK293, His)	P00740-1 (T29-T461)	≥ 95%, as determined by reducing SDS-PAGE.

F9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810760	Factor IX Antibody (YA10003)	WB, ICC/IF	Human, Mouse
HY-P81608	Factor IX Antibody (YA1353)	WB	Human

Related Diseases

Diseases	Alias
Hemophilia B	Christmas Disease Factor Ix Deficiency F9 Deficiency HEMB Plasma Thromboplastin Component Deficiency Congenital Factor Ix Deficiency Mild Hemophilia B Severe Hemophilia B Congenital Factor Ix Disorder Deficiency, Functional Factor Ix Hem B Mild Congenital F9 Deficiency Mild Congenital Factor Ix Deficiency Moderate Hemophilia B Moderate Congenital F9 Deficiency Moderate Congenital Factor Ix Deficiency Severe Congenital F9 Deficiency Severe Congenital Factor Ix Deficiency Bleeding Disorder In Hemophilia B Carriers Congenital F9 Deficiency Recessive X-Linked Hemophilia B
Thrombophilia, X-Linked, Due To Factor Ix Defect	THPH8 Deep Venous Thrombosis, Protection Against X-Linked Thrombophilia Due To Factor Ix Defect Thrombophilia, X-Linked, Due To Factor 9 Defect Thrombophilia 8, X-Linked, Due To Factor Ix Defect
Warfarin Sensitivity, X-Linked	Coumarin Sensitivity, X-Linked X-Linked Warfarin Sensitivity Warfarin Sensitivity WARFS
Hemophilia B Leyden	F9 Deficiency, Leyden Type Factor Ix Deficiency, Leyden Type
Hemophilia A	Factor Viii Deficiency Haemophilia A Mild Hemophilia A HEMA Hemophilia, Classic Classic Hemophilia Factor 8 Deficiency Severe Hemophilia A Classical Hemophilia Hem A Hemophilia A, Congenital Mild Congenital F8 Deficiency Mild Congenital Factor Viii Deficiency Severe Congenital F8 Deficiency Severe Congenital Factor Viii Deficiency Moderate Hemophilia A Moderate Congenital F8 Deficiency Moderate Congenital Factor Viii Deficiency Bleeding Disorder In Hemophilia A Carriers Congenital F8 Deficiency Congenital Fviii Deficiency Congenital Factor Viii Deficiency Mild Hereditary Factor Viii Deficiency Disease Severe Hereditary Factor Viii Deficiency Disease Ahg - [Antihaemophilic Globulin] Deficiency Ahg - [Antihaemophilic Globulin] Deficiency Disease Congenital Factor Viii Disorder Sex-Linked Factor Viii Deficiency Antihaemophilic Globulin Deficiency Classic Haemophilia Familial Haemophilia Haemophilia Hereditary Haemophilia Subhaemophilia Haemophilia Nos
Factor Viii Deficiency	Autosomal Hemophilia A Hemophilia A Autosomal Factor Viii Deficiency Classic Hemophilia A Congenital Factor Viii Disorder Subhemophilia Factor 8 Deficiency, Congenital Factor Viii
Hemophilia	Haemophilia Hemophilia, Familial Hemophilia, Hereditary Hemophilia A Hemophilia, Nos
Thrombophilia	Hypercoagulability State
Hemarthrosis	Haemarthrosis Of Shoulder Joint Haemarthrosis Of The Ankle And Foot Haemarthrosis Of The Pelvic Region And Thigh Hemarthrosis Involving Ankle And Foot Hemarthrosis Involving Forearm Hemarthrosis Involving Hand Hemarthrosis Involving Lower Leg Hemarthrosis Involving Pelvic Region And Thigh Hemarthrosis Involving Shoulder Region Hemarthrosis Involving Upper Arm Hemarthrosis Of Ankle And/Or Foot Hemarthrosis Of Forearm Hemarthrosis Of Hand Hemarthrosis Of Lower Leg Hemarthrosis Of Shoulder Hemarthrosis Of Shoulder Region Hemarthrosis Of The Ankle And Foot Hemarthrosis Of The Ankle And/Or Foot Hemarthrosis Of The Forearm Hemarthrosis Of The Hand Hemarthrosis Of The Lower Leg Hemarthrosis Of The Pelvic Region And Thigh Hemarthrosis Of The Shoulder Region Hemarthrosis Of The Upper Arm Hemarthrosis Of Upper Arm
Factor Xi Deficiency	Plasma Thromboplastin Antecedent Deficiency Rosenthal Syndrome Pta Deficiency Hemophilia C Rosenthal Factor Deficiency F11 Deficiency Congenital Factor Xi Deficiency Hereditary Factor Xi Deficiency Disease Haemophilia C Factor Xi Deficiency, Autosomal Dominant Rosenthal'S Disease Factor 11 Deficiency Factor Xi Factor Xi Deficiency, Autosomal Recessive Factor Xi Deficiency, Congenital FA11D Thromboplastin Antecedent Deficiency Pta - [Plasma Thromboplastin Antecedent] Deficiency Congenital Factor Xi Deficiency Disease Rosenthal Disease
Factor Vii Deficiency	Hypoproconvertinemia F7 Deficiency Congenital Proconvertin Deficiency Congenital Factor Vii Deficiency Factor 7 Deficiency Deficiency, Stable Proconvertin Deficiency Prothrombin Conversion Accelerator Deficiency Serum Prothrombin Conversion Accelerator Deficiency Proconvertin Deficiency, Congenital FA7D Stable Disease Deficiency, Factor Vii
Factor X Deficiency	Stuart-Prower Factor Deficiency F10 Deficiency Congenital Stuart Factor Deficiency Factor X Deficiency, Congenital Congenital Factor X Deficiency Disease, Stuart-Prower Stuart Factor Deficiency, Congenital FA10D Factor 10 Deficiency Deficiency, Factor X Hereditary Factor X Deficiency Disease Deficiency Of Factor X Stuart Deficiency Disease Stuart Prower Deficiency Stuart-Prower Disease
Thrombosis	Thrombosis Of Blood Vessel
Hemorrhagic Disease	Hemorrhagic Disorders Hemorrhagic Diathesis Hemorrhagic Diseases Bleeding Tendency Acquired Coagulation Factor Inhibitor Disorder Acquired Inhibitor Of Coagulation Antithrombinaemia Antithromboplastinogenaemia Circulating Anticoagulant Disorder Haemorrhagic Disorder Due To Antithrombinaemia Haemorrhagic Disorder Due To Excess Administered Heparin Antithromboplastinaemia Haemorrhagic Disorder Due To Hyperheparinemia
Protein C Deficiency	Hereditary Thrombophilia Due To Protein C Deficiency Proc Deficiency Congenital Thrombotic Disease, Due To Protein C Deficiency
Cardiac Tamponade	Pericardial Tamponade Rose'S Tamponade
Von Willebrand'S Disease	Von Willebrand Disease Von Willebrand Disorder Vascular Pseudohemophilia Hereditary Von Willebrand Disease Vwd Vascular Hemophilia Von Willebrand'S-Jurgens' Disease Von Willebrand-Jrgens Disease Von Willebrand Factor Deficiency Von Willebrand Factor, Deficiency Angiohemophilia Von Willebrand'S Factor Deficiency Von Willebrand Diseases Factor Viii Deficiency With Vascular Defect Vascular Haemophilia Willebrand Jurgen Thrombopathy Pseudohaemophilia Minot-Von Willebrand-Jurgen Disease Angiohaemophilia Angiohaemophilia A Angiohaemophilia B
Factor V Deficiency	Parahemophilia Labile Factor Deficiency Proaccelerin Deficiency Owren Disease Owren Parahemophilia Quebec Platelet Disorder Deficiency, Labile Hereditary Hypoproaccelerinaemia Owren'S Disease Congenital Factor V Deficiency FA5D Factor 5 Deficiency Deficiency, Factor V
Arthropathy	Ankylosis Of Ankle And Foot Joint Ankylosis Of Forearm Joint Ankylosis Of Hand Joint Ankylosis Of Joint Of Ankle And/Or Foot Ankylosis Of Joint Of Forearm Ankylosis Of Joint Of Hand Ankylosis Of Joint Of Lower Leg Ankylosis Of Joint Of Multiple Sites Ankylosis Of Joint Of Pelvic Region And Thigh Ankylosis Of Joint Of Shoulder Region Ankylosis Of Joint Of Upper Arm Ankylosis Of Lower Leg Joint Ankylosis Of Multiple Joints Ankylosis Of Upper Arm Joint Infectious Arthropathy Joint Ankylosis Of The Ankle And Foot Joint Ankylosis Of The Ankle And/Or Foot Joint Ankylosis Of The Forearm Joint Ankylosis Of The Hand Joint Ankylosis Of The Lower Leg Joint Ankylosis Of The Pelvic Region And Thigh Joint Ankylosis Of The Shoulder Region Joint Ankylosis Of The Upper Arm Joint Diseases Joint Disease Arthropathy Associated With Infection
Disseminated Intravascular Coagulation	Defibrination Syndrome Dic Diffuse Or Disseminated Intravascular Coagulation Fibrinolytic Purpura Consumption Coagulopathy Diffuse Intravascular Coagulation Dic - [Disseminated Intravascular Coagulation] Disseminated Intravascular Coagulopathy Fibrinolysis Nos Thrombolytic Purpura
Factor Xii Deficiency	Hageman Factor Deficiency Haf Deficiency Factor Xii Deficiency Disease F12 Deficiency Deficiency, Hageman Coagulation Factor 12 Deficiency Factor 12 Deficiency Congenital Factor Xii Deficiency Congenital Hageman Factor Deficiency FA12D Factor Xii Deficiency, Factor Xii
Sneddon Syndrome	Livedo Reticularis And Cerebrovascular Accidents SNDNS Ehrmann-Sneddon Syndrome Livedo Racemosa-Cerebrovascular Accident Syndrome Livedo Reticularis-Cerebrovascular Accident Syndrome Sneddon'S Syndrome Idiopathic Livedo Reticularis With Systemic Involvement Cerebro-Vascular Lesions And Livedo Reticularis Livedo Racemosa And Cerebrovascular Accidents
Atrial Fibrillation	A-Fib Fibrillation, Atrial Af - [Atrial Fibrillation] Rapid Atrial Fibrillation A Fib - [Atrial Fibrillation]
Immunoglobulin Light Chain Amyloidosis	Al Amyloidosis Primary Amyloidosis Primary Systemic Amyloidosis Light Chain Amyloidosis Amyloidosis Al Amyloidosis Primary Systemic Primary Al Amyloidosis Primary Systemic Al Amyloidosis Systemic Al Amyloidsis Systemic Al Amyloidosis Light-Chain Amyloidosis Alys Amyloidosis Familial Amyloid Nephropathy Due To Lysozyme Variant Familial Renal Amyloidosis Due To Lysozyme Variant Hereditary Amyloid Nephropathy Due To Lysozyme Variant Hereditary Renal Amyloidosis Due To Lysozyme Variant Lysozyme Amyloidosis Amyloidosis Primary Immunoglobulin Deposition Disease Immunoglobulinic Amyloidosis Amyloid Al
Pulmonary Embolism	Pulmonary Artery Embolism Pulmonary Embolus Pulmonary Emboli
Thrombophilia Due To Activated Protein C Resistance	Activated Protein C Resistance Apc Resistance THPH2 Thrombophilia Due To Deficiency Of Activated Protein C Cofactor Proc Cofactor Deficiency Pccf Deficiency Thrombophilia V Thrombophilia, Susceptibility To, Due To Factor V Leiden Thrombophilia Due To Factor V Leiden Thrombophilia 2 Due To Activated Protein C Resistance Thrombophilia, Susceptibility To, Due To Activated Protein C Resistance
Glanzmann Thrombasthenia 1	Glanzmann Thrombasthenia Thrombasthenia Of Glanzmann And Naegeli Glanzmann'S Thrombasthenia Bdplt2 Platelet Glycoprotein Iib-Iiia Deficiency Deficiency Of Platelet Fibrinogen Receptor GT1 Gt Platelet Fibrinogen Receptor Deficiency Glycoprotein Complex Iib-Iiia Deficiency Deficiency Of Glycoprotein Complex Iib-Iiia Glycoprotein Iib/Iiia Defect Glanzmann Thrombasthenia, Type A Thrombasthenia Bleeding Disorder, Platelet-Type, 2 Gp Iib-Iiia Complex Deficiency Deficiency Of Gp Iib-Iiia Complex Platelet-Type Bleeding Disorder 2 Thrombocytasthenia Deficiency Of Gp 2b 3a Complex Diacyclothrombopathia 2b 3a Glanzmann Thrombasthenia Type A Platelet Fibrinogen Receptor, Deficiency Of Platelet Glycoprotein 2b 3a Deficiency Glanzmann Disease Glanzmann-Naegeli Disorder Hereditary Hemorrhagic Thrombasthenia Hereditary Thrombasthenia Bleeding Disorder Platelet-Type 2
Color Blindness	Color Vision Defect Blindness Color Colour Blindness Colour Vision Deficiency Color Vision Deficiency Color Vision Defects Defective Color Vision Vision Defect, Color Color-Vision Disease Dyschromatopsia
Congenital Disorder Of Glycosylation, Type Ia	CDG1A Cdg Ia Phosphomannomutase 2 Deficiency Jaeken Syndrome Pmm2-Congenital Disorder Of Glycosylation Congenital Disorder Of Glycosylation Type Ia Cdgia Congenital Disorder Of Glycosylation Ia Congenital Disorder Of Glycosylation 1a Carbohydrate-Deficient Glycoprotein Syndrome Type Ia Cdgs1a Pmm2-Cdg Cdg-Ia Congenital Disorder Of Glycosylation Type 1a Carbohydrate-Deficient Glycoprotein Syndrome, Type Ia, Formerly Pmm Deficiency Cdg Syndrome Type Ia Carbohydrate Deficient Glycoprotein Syndrome Type Ia Cdg Syndrome Type 1a Jaeken'S Syndrome Pmm2 Deficiency Glycosylation, Congenital Disorder Of, Type Ia
Retinal Artery Occlusion	Retina Artery Narrowing Retinal Artery Spasm Spasm Of Ophthalmic Artery Retinal Spasm Vasospasm Of Retina
Intracranial Hypertension	Raised Intracranial Pressure
Brachydactyly, Type D	Brachydactyly Type D BDD Stub Thumb Brachydactyly D
Blood Coagulation Disease	Blood Coagulation Disorders Coagulation Protein Disease Inherited Blood Coagulation Disease Postpartum Coagulation Defect Postpartum Coagulation Defect With Delivery Coagulation Protein Disorders Puerperal Coagulopathy
Dilated Cardiomyopathy 1t	Cmd1t Cardiomyopathy, Dilated, 1t
Thrombophilia Due To Thrombin Defect	Venous Thromboembolism Venous Thrombosis Thrombophilia Due To Factor 2 Defect Thromboembolism THPH1 Thromboembolism, Susceptibility To Venous Thromboembolism, Susceptibility To Venous Thrombosis, Protection Against Prothrombin-Related Thrombophilia Hyperprothrombinemia Venous Thrombosis, Susceptibility To Thrombophilia 1 Due To Thrombin Defect F2-Related Thrombophilia Factor Ii-Related Thrombophilia Prothrombin 20210g>A Thrombophilia Prothrombin G20210a Thrombophilia Prothrombin Thrombophilia
Coumarin Resistance	Warfarin Resistance Warfarin Sensitivity Coumadin Sensitivity Warfarin Response Poor Metabolism Of Coumarin Coumarin, Poor Metabolism Of CMRES
Bernard-Soulier Syndrome	Giant Platelet Syndrome BSS Von Willebrand Factor Receptor Deficiency Bdplt1 Platelet Glycoprotein Ib Deficiency Bernard-Soulier Syndrome, Type A1 Bernard-Soulier Syndrome, Type B Bernard Soulier Syndrome Deficiency Of Platelet Glycoprotein 1b Hemorrhagiparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type C Bleeding Disorder, Platelet-Type, 1 Glycoprotein Ib, Platelet, Deficiency Of Giant Platelet Disorder, Isolated Giant Platelet Disease Macrothrombocytopenia, Familial Bernard-Soulier Type Bernard-Soulier Syndrome, Type C Bernard - Soulier Thrombopathy Hemorrhagic Dystrophic Thrombocytopenia Thrombopathy, Bernard-Soulier Platelet Glycoprotein 1b, Deficiency Of Hemorrhagioparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type A1 Bernard-Soulier Syndrome Type B Bleeding Disorder Platelet-Type 1 Gpd Macrothrombocytopenia, Familial, Bernard-Soulier Type
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Ornithine Transcarbamylase Deficiency, Hyperammonemia Due To	Ornithine Carbamoyltransferase Deficiency Ornithine Transcarbamylase Deficiency Otc Deficiency Ornithine Carbamoyltransferase Deficiency Disease OTCD Deficiency Of Citrulline Phosphorylase Oct Deficiency Hyperammonemia Due To Ornithine Carbamoyltransferase Deficiency Deficiency, Ornithine Carbamoyltransferase
Vitamin K Deficiency Bleeding	Vitamin K Deficiency Deficiency Of Vitamin K Vitamin K Vitamin K Deficiency Hemorrhagic Disease
Prothrombin Deficiency	Factor Ii Deficiency Hypoprothrombinemia Dysprothrombinemia Deficiency, Prothrombin Inherited Factor Ii Deficiency Hereditary Factor Ii Deficiency Disease
Acquired Immunodeficiency Syndrome	Acquired Immune Deficiency Syndrome AIDS Acquired Immune Deficiency Acquired Immunodeficiency Acquired Immunodeficiency Due To Protein Loss
Factor Xiii Deficiency	Hereditary Factor Xiii Deficiency Disease Deficiency, Laki-Lorand Factor Congenital Factor Xiii Deficiency Fibrin Stabilizing Factor Deficiency Deficiency, Factor Xiii Factor Xiii Deficiency Disease Deficiency Of Factor Xiii Fibrin-Stabilizing Factor Deficiency Factor Xiii Deficiency, Congenital
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Compartment Syndrome	Compartment Syndromes Compartmental Syndrome
Tyrosinemia, Type I	Tyrosinemia Type I Hepatorenal Tyrosinemia Fumarylacetoacetase Deficiency Fah Deficiency TYRSN1 Fumarylacetoacetate Hydrolase Deficiency Tyrosinemia Type 1 Tyrosinemia 1 Fumarylacetoacetase
Ulcer Of Lower Limbs	Ulcer Of Ankle Ulcer Of Calf Ulcer Of Heel And Midfoot Ulcer Of Thigh Ulcer Of Lower Limb
Gaucher'S Disease	Gaucher Disease Kerasin Thesaurismosis Glucocerebrosidase Deficiency Glucosylceramidase Deficiency Cerebroside Lipidosis Syndrome Acid Beta-Glucosidase Deficiency Glucosylceramide Beta-Glucosidase Deficiency Acute Cerebral Gaucher Disease Gaucher Splenomegaly Glucocerebrosidosis Glucosyl Cerebroside Lipidosis Kerasin Lipoidosis Lipoid Histiocytosis Glocucerebrosidase Deficiency Sphingolipidosis 1 Gaucher Syndrome Gauchers Disease Gd Glucosylceramide Lipidosis Kerasin Histiocytosis Gaucher Disease, Type 1 Gaucher Disease, Type 2
Mucopolysaccharidosis, Type Ii	Hunter Syndrome Iduronate 2-Sulfatase Deficiency Mucopolysaccharidosis Ii Mps Ii Mucopolysaccharidosis Type Ii MPS2 Sulfoiduronate Sulfatase Deficiency Mucopolysaccharidosis, Mps-Ii Ids Deficiency Sids Deficiency I2s Deficiency Mucopolysaccharidosis Type 2 Mucopolysaccharidosis Type 2, Severe Form Deficiency Of Iduronate-2-Sulphatase Hunter'S Syndrome Mps Ii - Hunter Syndrome Iduronate-2-Sulfatase Deficiency Attenuated Mps Mps 2 Severe Mps Ii Mpsii Mucopolysaccharidosis Type 2, Attenuated Form Hunter Syndrome Type B Iduronate 2-Sulfatase Deficiency Type B Mps2b Mpsiib Mucopolysaccharidosis Type 2b Mucopolysaccharidosis Type Ii, Attenuated Form Mucopolysaccharidosis Type Iib Hunter Syndrome Type A Iduronate 2-Sulfatase Deficiency Type A Mps2a Mpsiia Mucopolysaccharidosis Type 2a Mucopolysaccharidosis Type Ii, Severe Form Mucopolysaccharidosis Type Iia Mucopolysaccharidosis 2 Hunters Syndrome Iduronate 2-Sulphatase Deficiency Iduronate Sulfatase Deficiency Iduronate Sulphatase Deficiency Sulfo-Iduronate Sulfatase Deficiency Sulfoiduronidate Sulfatase Deficiency Sulpho-Iduronate Sulphatase Deficiency Sulphoiduronidate Sulphatase Deficiency Mps2 - [Mucopolysaccharidosis 2]
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Adenosine Deaminase Deficiency	Ada Deficiency Ada-Scid Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency Adenosine Deaminase Deficient Severe Combined Immunodeficiency Scid Due To Ada Deficiency Severe Combined Immunodeficiency Due To Ada Deficiency Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency Ada Scid Due To Adenosine Deaminase Deficiency
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Crigler-Najjar Syndrome, Type I	Crigler-Najjar Syndrome Crigler-Najjar Syndrome Type 1 Bilirubin Udp Glucuronyl Transferase Deficiency Crigler Najjar Syndrome Crigler Najjar Syndrome, Type 1 Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Bilirubin-Ugt Deficiency Hyperbilirubinemia, Crigler-Najjar Type I Hblrcn1 Familial Nonhemolytic Unconjugated Hyperbilirubinemia Hereditary Unconjugated Hyperbilirubinemia Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1 Bilirubin-Ugt Deficiency Type 1 Crigler-Najjar Syndrome 1 CN1 Cn-I Crigler-Najjar Syndrome Type I Hereditary Unconjugated Hyperbilirubinaemia Ugt Deficiency Bilirubin Glucuronosyltransferase Deficiency Crigler-Najjar Disease Or Syndrome Deficiency Of Glucuronosyltransferase Glucuronyl Transferase Deficiency Glucuronyltransferase Deficiency Udp Glucuronyl Transferase Deficiency Cns - [Crigler-Najjar Syndrome] Congenital Familial Nonhemolytic Jaundice
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14649G	Retinoic acid (GMP)	Agonist	/	Phase 3

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99029	Magrolimab	Inhibitor	99.92%	Phase 3

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13631N	(9R)-Exatecan	Inhibitor	/	Unkown
HY-155741	CB2 PET Radioligand 1		/	Unkown
HY-158320	T3SS-IN-5		/	Unkown
HY-162131	Antitumor agent-132		/	Unkown
HY-RS04648	F9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-13589	Cemadotin	Inhibitor	/	Unkown
HY-RS17724	F9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24189	F9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99145	Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2)	Inhibitor	99.68%	Unkown
HY-P99232	Indusatumab		≥99.0%	Unkown
HY-P99145A	Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2-Mouse IgG1)	Inhibitor	95.00%	Unkown
HY-P990171	Anti-Mouse PD-L1/B7-H1 (LALA-PG) Antibody (10F.9G2)	Inhibitor	99.46%	Unkown
HY-P9940A	Emicizumab (Anti-F9 & Factor IX)	Inhibitor	99.69%	Unkown
HY-P991169	Zemocimig	Inhibitor	95.59%	Unkown
HY-P990172	Anti-Mouse PD-L1/B7-H1 (D265A) Antibody (10F.9G2)	Inhibitor	99.32%	Unkown
HY-P992155	Arevirumab	Inhibitor	/	Unkown
HY-P992203	Anti-CD172a Antibody (3F9)		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	F9	MGD	MGI:88384
Macaca mulatta	F9	VGNC	VGNC:72468
Felis catus	F9	VGNC	VGNC:62029
Bos taurus	F9	VGNC	VGNC:28691
Canis familiaris	F9	VGNC	VGNC:40554
Rattus norvegicus	F9	RGD	RGD:2589
Others	F9	NCBI